“Kartal Dr. Lütfi Kırdar City Hospital” is one of the Turkey’s largest and most important hospital and become entitled to get certificate of LEED Gold. The project is also Turkey’s first and the world’s largest EDGE certified green hospital.As a sustainability considering project, “Kartal Dr. Lütfi Kırdar City Hospital” is designed and constructed close to public transport and social facilities, located in a previously developed land. In order to minimize the adverse effect on the environment, erosion and sedimentation plans are developed, precautions are taken to prevent water and construction pollution caused by dust generation. Efficient water fixtures lead to water saving in a significant value. With the selection of energy-efficient mechanical-electrical systems, stratified facades and high performance glass, 42% energy saving is provided when compared to international standards. Required infrastructure and automation monitoring systems are designed in order to watch system’s energy consumption separately. Fresh air amount is set above the international standards and VOC content of the building construction chemicals that used during the construction of interior spaces, are selected to be the lowest ratio in order to increase interior living health and comfort. The facade design provide maximum daylight for the patient and inpatient areas.